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KMID : 1141820220220010056
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Journal of Gastric Cancer
2022 Volume.22 No. 1 p.56 ~ p.66
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Nutritional Status Indicators Affecting the Tolerability of Postoperative Chemotherapy After Total Gastrectomy in Patients With Gastric Cancer
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Toyota Kazuhiro
Mori Masayuki
Hirahara Satoshi
Yoshioka Shoko
Kubota Haruna
Yano Raita
Kobayashi Hironori
Hashimoto Yasushi
Sakashita Yoshihiro
Yokoyama Yujiro
Murakami Yoshiaki
Miyamoto Katsunari
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Abstract
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Purpose: Nutritional problems after gastrectomy affect continuation of postoperative chemotherapy. There have been no studies limited to total gastrectomy, which is particularly prone to nutritional problems. In this study, we aimed to investigate the factors that predict the continuation of postoperative chemotherapy.
Materials and Methods: We included 101 patients who underwent curative total gastrectomy and postoperative chemotherapy at Hiroshima Memorial Hospital. The effects of 37 factors, including perioperative inflammatory, nutritional, and tumor status, on the persistence of postoperative chemotherapy were analyzed.
Results: In univariate analysis of preoperative factors, age, carbohydrate antigen 19-9, platelet-to-neutrophil ratio, Onodera's prognostic nutritional index (PNI), controlling nutritional status score, and nutritional risk screening (NRS-2002) score were significantly associated with the duration of postoperative chemotherapy. In multivariate analysis of preoperative factors, age (≥74 years) was an independent factor for a shorter duration of postoperative chemotherapy (hazard ratio [HR], 5.24; 95% confidence interval [CI], 2.19?12.96; P<0.01). In univariate analysis of factors before postoperative chemotherapy, intraoperative blood loss, perioperative weight loss rate, postoperative performance status, PNI, albumin-to-bilirubin index, and NRS-2002 score were significantly associated with the duration of postoperative chemotherapy. In multivariate analysis of factors before postoperative therapy, age (≥74 years) (HR, 5.75; 95% CI, 1.90?19.49; P<0.01) and PNI (<39) (HR, 3.29; 95% CI, 1.26?8.56; P=0.02) were independent factors for a shorter duration of postoperative chemotherapy.
Conclusions: Age and PNI are useful predictors of postoperative chemotherapy intolerance after total gastrectomy and may determine the treatment strategy and timing of chemotherapy initiation.
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KEYWORD
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Gastric cancer, Total gastrectomy, Postoperative chemotherapy, Nutritional assessment, Prognostic nutritional index
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